EFFECT OF ULTRAHIGH-DOSE METHYLCOBALAMIN ON COMPOUND MUSCLE ACTION-POTENTIALS IN AMYOTROPHIC-LATERAL-SCLEROSIS - A DOUBLE-BLIND CONTROLLED-STUDY

Citation
R. Kaji et al., EFFECT OF ULTRAHIGH-DOSE METHYLCOBALAMIN ON COMPOUND MUSCLE ACTION-POTENTIALS IN AMYOTROPHIC-LATERAL-SCLEROSIS - A DOUBLE-BLIND CONTROLLED-STUDY, Muscle & nerve, 21(12), 1998, pp. 1775-1778
Citations number
8
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
0148-639X
Volume
21
Issue
12
Year of publication
1998
Pages
1775 - 1778
Database
ISI
SICI code
0148-639X(1998)21:12<1775:EOUMOC>2.0.ZU;2-5
Abstract
To develop a symptomatic treatment for amyotrophic lateral sclerosis, we compared the effects of ultrahigh-dose and low-dose (25 and 0.5 mg/ day, intramuscularly, for 14 days) methylcobalamin on averaged compoun d muscle action potential amplitudes (CMAPs) in a double-blind trial. No significant changes in CMAP amplitude were found in 12 patients who had the low-dose treatment at either 2 or 4 weeks after start of trea tment. By contrast, 12 patients assigned to the ultrahigh-dose group d emonstrated a significant increase at 4 weeks. This method may provide a clinically useful measure to improve or retard muscle wasting, if a larger extended trial fulfills its promise. (C) 1998 John Wiley & Son s, Inc.