NATURAL-HISTORY AND PROGNOSIS OF ADENOMATOUS HYPERPLASIA AND EARLY HEPATOCELLULAR-CARCINOMA - MULTIINSTITUTIONAL ANALYSIS OF 53 NODULES FOLLOWED UP FOR MORE THAN 6 MONTHS AND 141 PATIENTS WITH SINGLE EARLY HEPATOCELLULAR-CARCINOMA TREATED BY SURGICAL RESECTION OR PERCUTANEOUS ETHANOL INJECTION
M. Sakamoto et S. Hirohashi, NATURAL-HISTORY AND PROGNOSIS OF ADENOMATOUS HYPERPLASIA AND EARLY HEPATOCELLULAR-CARCINOMA - MULTIINSTITUTIONAL ANALYSIS OF 53 NODULES FOLLOWED UP FOR MORE THAN 6 MONTHS AND 141 PATIENTS WITH SINGLE EARLY HEPATOCELLULAR-CARCINOMA TREATED BY SURGICAL RESECTION OR PERCUTANEOUS ETHANOL INJECTION, Japanese Journal of Clinical Oncology, 28(10), 1998, pp. 604-608
Background: The natural history and posttherapeutic outcome of adenoma
tous hyperplasia and early hepatocellular carcinoma have rarely been a
nalyzed, Methods: Fifty-three hepatic tumors diagnosed as adenomatous
hyperplasia or early hepatocellular carcinoma and followed up for more
than 6 months and 141 patients with single early hepatocellular carci
noma treated by surgical resection or ethanol injection were collected
retrospectively and analyzed. Results: Some of the adenomatous hyperp
lasias developed to early and to advanced hepatocellular carcinoma. Tu
mors tended to grow faster in the order adenomatous hyperplasia, early
hepatocellular carcinoma and advanced hepatocellular carcinoma, with
respective mean (SD) tumor volume doubling times of 21.2 (10.7), 13.9
(11.7) and 6.0 (5.2) months. Overall survival rates at 5 years in 53 p
atients treated by surgery and 88 patients treated by ethanol injectio
n were 89.6 and 71.9%, respectively. Conclusion: Progression of adenom
atous hyperplasia and early HCC was confirmed pathologically. Early HC
C was shown to have a good prognosis.