NATURAL-HISTORY AND PROGNOSIS OF ADENOMATOUS HYPERPLASIA AND EARLY HEPATOCELLULAR-CARCINOMA - MULTIINSTITUTIONAL ANALYSIS OF 53 NODULES FOLLOWED UP FOR MORE THAN 6 MONTHS AND 141 PATIENTS WITH SINGLE EARLY HEPATOCELLULAR-CARCINOMA TREATED BY SURGICAL RESECTION OR PERCUTANEOUS ETHANOL INJECTION

Citation
M. Sakamoto et S. Hirohashi, NATURAL-HISTORY AND PROGNOSIS OF ADENOMATOUS HYPERPLASIA AND EARLY HEPATOCELLULAR-CARCINOMA - MULTIINSTITUTIONAL ANALYSIS OF 53 NODULES FOLLOWED UP FOR MORE THAN 6 MONTHS AND 141 PATIENTS WITH SINGLE EARLY HEPATOCELLULAR-CARCINOMA TREATED BY SURGICAL RESECTION OR PERCUTANEOUS ETHANOL INJECTION, Japanese Journal of Clinical Oncology, 28(10), 1998, pp. 604-608
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
ISSN journal
0368-2811
Volume
28
Issue
10
Year of publication
1998
Pages
604 - 608
Database
ISI
SICI code
0368-2811(1998)28:10<604:NAPOAH>2.0.ZU;2-5
Abstract
Background: The natural history and posttherapeutic outcome of adenoma tous hyperplasia and early hepatocellular carcinoma have rarely been a nalyzed, Methods: Fifty-three hepatic tumors diagnosed as adenomatous hyperplasia or early hepatocellular carcinoma and followed up for more than 6 months and 141 patients with single early hepatocellular carci noma treated by surgical resection or ethanol injection were collected retrospectively and analyzed. Results: Some of the adenomatous hyperp lasias developed to early and to advanced hepatocellular carcinoma. Tu mors tended to grow faster in the order adenomatous hyperplasia, early hepatocellular carcinoma and advanced hepatocellular carcinoma, with respective mean (SD) tumor volume doubling times of 21.2 (10.7), 13.9 (11.7) and 6.0 (5.2) months. Overall survival rates at 5 years in 53 p atients treated by surgery and 88 patients treated by ethanol injectio n were 89.6 and 71.9%, respectively. Conclusion: Progression of adenom atous hyperplasia and early HCC was confirmed pathologically. Early HC C was shown to have a good prognosis.