EFFECTS OF GESTATIONAL EXPOSURE TO A VIDEO DISPLAY TERMINAL-LIKE MAGNETIC-FIELD (20-KHZ) ON CBA S MICE/

Citation
H. Huuskonen et al., EFFECTS OF GESTATIONAL EXPOSURE TO A VIDEO DISPLAY TERMINAL-LIKE MAGNETIC-FIELD (20-KHZ) ON CBA S MICE/, Teratology, 58(5), 1998, pp. 190-196
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Toxicology,"Developmental Biology
Journal title
ISSN journal
0040-3709
Volume
58
Issue
5
Year of publication
1998
Pages
190 - 196
Database
ISI
SICI code
0040-3709(1998)58:5<190:EOGETA>2.0.ZU;2-C
Abstract
Possible adverse effects of magnetic fields (MFs) on reproduction have been an open question. To verify the embryo-lethal effect of pulsed M F of the type emitted by video display terminals (VDTs) reported previ ously in CBA/S mice, a developmental toxicity study was conducted in a nimals of the same origin. Mated CBA/S mice (80-86 pregnant animals pe r group) were exposed to a 20-kHz MF with sawtooth waveform continuous ly from gestational day 0-18. The flux density of the vertical MF was 15 mu T peak-to-peak (150 mG). This field was previously reported to i ncrease the number of resorptions in CBA/S mice. On gestational day 18 , the dams were killed and blood and bone marrow samples were taken fo r hematology and micronuclei analysis, respectively. The number of cor pora lutea was counted and the content of the uterus examined. There w ere no statistically significant differences in maternal or fetal body weights, number of corpora lutea, implantations, resorptions, dead an d live fetuses, or external and skeletal malformations. MF did not alt er the number of blood cells or cause micronuclei in bone marrow eryth rocytes in the dams. The mean number of resorptions was slightly but n ot statistically significantly, higher in the MF group than in control s. The results do not indicate marked developmental, hematological, or clastogenic effects of 20-kHz MFs. Teratology 58:190-196, 1998. (C) 1 998 Wiley-Liss, Inc.