CYTOTOXIC EFFECTS OF QUINOXALINE DERIVATIVES ON HUMAN CANCER CELL-LINES

Citation
Hw. Yoo et al., CYTOTOXIC EFFECTS OF QUINOXALINE DERIVATIVES ON HUMAN CANCER CELL-LINES, Archiv der pharmazie, 331(10), 1998, pp. 331-333
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal",Chemistry
Journal title
ISSN journal
0365-6233
Volume
331
Issue
10
Year of publication
1998
Pages
331 - 333
Database
ISI
SICI code
0365-6233(1998)331:10<331:CEOQDO>2.0.ZU;2-1
Abstract
The cytotoxicities of 6,7-modified-5,8-quinoxalinedione derivatives an d heterocyclic quinoxaline derivatives containing nitrogen, sulfur, an d oxygen on human lung adenocarcinoma cell (PC 14), human gastric aden ocarcinoma cell (MKN 45), and human colon adenocarcinoma cell (colon 2 05) were examined in vitro, using MTT assay. Pyrido[1,2-a]imidazo[4,5- g] quinoxaline-6,11-dione (10) was markedly cytotoxic against MKN 45 c ompared with adriamycin and cis-platin used as anticancer drugs. The I C50 value of compound 10 was 0.073 mu M while those of adriamycin and cis-platin were 0.12 mu M and 2.67 mu M, respectively.