BINDING OF CDK9 TO TRAF2

Citation
Tk. Maclachlan et al., BINDING OF CDK9 TO TRAF2, Journal of cellular biochemistry, 71(4), 1998, pp. 467-478
Citations number
40
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology,"Cell Biology
ISSN journal
0730-2312
Volume
71
Issue
4
Year of publication
1998
Pages
467 - 478
Database
ISI
SICI code
0730-2312(1998)71:4<467:>2.0.ZU;2-M
Abstract
CDK9 has been recently shown to have increased kinase activity in diff erentiated cells in culture and a differentiated tissue-specific expre ssion in the developing mouse. In order to identify factors that contr ibute to CDK9's differentiation-specific function, we screened a mouse embryonic library in the yeast two-hybrid system and found a tumor ne crosis factor signal transducer, TRAF2, to be an interacting protein. CDK9 interacts with a conserved domain in the TRAF-C region of TRAF2, a motif that is known to bind other kinases involved in TRAF-mediated signaling. Endogenous interaction between the two proteins appears to be specific to differentiated tissue. TRAF2-mediated signaling may inc orporate additional kinases to signal cell survival in myotubes, a cel l type that is severely affected in TRAF2 knockout mice. (C) 1998 Wile y-Liss, Inc.