TRAF2 EXPRESSION IN DIFFERENTIATED MUSCLE

Citation
Tk. Maclachlan et A. Giordano, TRAF2 EXPRESSION IN DIFFERENTIATED MUSCLE, Journal of cellular biochemistry, 71(4), 1998, pp. 461-466
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology,"Cell Biology
ISSN journal
0730-2312
Volume
71
Issue
4
Year of publication
1998
Pages
461 - 466
Database
ISI
SICI code
0730-2312(1998)71:4<461:TEIDM>2.0.ZU;2-#
Abstract
Recent data involving traf2 knockout mice have suggested a necessity o f the protein in viability of skeletal muscle tissue. traf2 -/- mice a re born with decreased muscle mass that is hypothesized to be due to t he increased circulating tumor necrosis factor in these mice. We show that TRAF2 protein is present at high levels in terminally differentia ted skeletal muscle in the developing mouse. In vitro differentiation of mouse myoblasts displays a dramatic increase in TRAF2 protein level s. Although basal NF-KB activity decreases during myogenesis, TNF-indu ced NF-KB activity is 10 times greater in myotubes compared with myobl asts, presumably because of the stockpiling of TRAF2 protein in these cells. This may represent a strong anti-apoptotic TRAF2-mediated respo nse specifically tailored to myotubes. These data help explain why mus cle integrity is at risk in traf2 -/- mice. (C) 1998 Wiley-Liss, Inc.