EPIZOOTICS OF CANCER IN FISH ASSOCIATED WITH GENOTOXINS IN SEDIMENT AND WATER

Authors
Citation
Pc. Baumann, EPIZOOTICS OF CANCER IN FISH ASSOCIATED WITH GENOTOXINS IN SEDIMENT AND WATER, Mutation research. Reviews in mutation research, 411(3), 1998, pp. 227-233
Citations number
48
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Genetics & Heredity",Toxicology,"Biothechnology & Applied Migrobiology
ISSN journal
1383-5742
Volume
411
Issue
3
Year of publication
1998
Pages
227 - 233
Database
ISI
SICI code
1383-5742(1998)411:3<227:EOCIFA>2.0.ZU;2-O
Abstract
Neoplasm epizootics in fish from a wide variety of freshwater, marine, and estuarine locations have been associated with genotoxins in sedim ent or water. The majority of cases have involved benthic or bottom fe eding fish Living in habitats with sediment contaminated by PAHs. The most common lesions involved in such epizootics include Liver neoplasm s, both biliary and hepatic, and skin neoplasms. Laboratory research h as demonstrated the ability of fish to metabolize carcinogenic PAHs su ch as B(a)P into the ultimate carcinogen with the resulting formation of DNA adducts. Fish dosed with B(a)P or sediment extracts containing carcinogenic PAHs have developed skin and liver neoplasms. In the Blac k River, OH, neoplasm prevalence in wild brown bullhead has reflected PAH exposure as the latter has changed due to coke plant closures and remedial dredging activity. The weight of evidence supports a cause-an d-effect relationship between exposure to genotoxins in sediment and w ater and neoplasm epizootics in wild fish populations. (C) 1998 Elsevi er Science B.V. All rights reserved.