CEREBRAL OXYGENATION DURING PROSTAGLANDIN E-1 INDUCED HYPOTENSION

Citation
Y. Kadoi et al., CEREBRAL OXYGENATION DURING PROSTAGLANDIN E-1 INDUCED HYPOTENSION, Canadian journal of anaesthesia, 45(9), 1998, pp. 860-864
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Anesthesiology
ISSN journal
0832-610X
Volume
45
Issue
9
Year of publication
1998
Pages
860 - 864
Database
ISI
SICI code
0832-610X(1998)45:9<860:CODPEI>2.0.ZU;2-Y
Abstract
Purpose: To evaluate the cerebral oxygenation effects of hypotension i nduced by prostaglandin E-1(PGE(1)) during fentanyl-oxygen anaesthesia . Methods: Ten patients who underwent elective cardiac surgery receive d infusion of PGE(1). After measuring the baseline arterial, mixed ven ous and internal jugular vein blood gases, systemic haemodynamics, and regional cerebral oxygen saturation (rSO(2)) estimated by INVOS 3100( R), PGE(1) was continuously infused at 0.25-0.65 mu g.kg(-1).min(-1) ( mean dosage: 410 +/- 41.4 mg.kg(-1).min(-1)) intravenously. Ten, 20 an d 30 minutes after the start of drug infusions, blood gases described above were obtained simultaneously with the measurement of systemic ha emodynamics and rSO(2). Thirty minutes from the start of drug infusion s, administration of PGE(1) was stopped. The same parameters were meas ured again 10, 30 minutes after the stop of drug infusion. Results: PG E(1) decreased mean arterial pressure (MAP) to approximately 70% of th e baseline value (P < 0.05). PGE(1) increased mixed venous saturation, but in contrast did not effect internal jugular pressure, internal ju gular oxygen saturation and rSO(2). Conclusions: These results suggest that PGE(1) is a suitable drug for induced hypotension because flow/m etabolism coupling of brain and regional cerebral oxygenation were wel l maintained during hypotension.