IMPROVED POSTOPERATIVE ANALGESIA WITH ISOFLURANE THAN WITH PROPOFOL ANESTHESIA

Citation
G. Boccara et al., IMPROVED POSTOPERATIVE ANALGESIA WITH ISOFLURANE THAN WITH PROPOFOL ANESTHESIA, Canadian journal of anaesthesia, 45(9), 1998, pp. 839-842
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Anesthesiology
ISSN journal
0832-610X
Volume
45
Issue
9
Year of publication
1998
Pages
839 - 842
Database
ISI
SICI code
0832-610X(1998)45:9<839:IPAWIT>2.0.ZU;2-7
Abstract
Purpose: The impact of hypnotic drugs on postoperative analgesia has n ot been evaluated, We compared the influence of the maintenance of ana esthesia with either propofol or isoflurane on postoperative pain. Met hods: Forty ASA 1-2 women. undergoing cosmetic abdominoplasty were ran domized to receive either 6-12 mg.kg(-1).hr(-1) propofol iv (P, n = 20 ) or MAC 1-1.5 isoflurane inhalation (Iso, n = 20). The lungs were ven tilated with N2O 60% and O-2 40%, and 1 mu g.kg(-1) fentanyl iv provid ed intraoperative analgesia. Before surgical closure. 2 g propacetamol iv were administered. Postoperative analgesia was provided after hour ly assessment of pain (VAS 0-100 mm), with 10 mg nalbuphine iv if VAS greater than or equal to 50 mm, during the eight hours after surgery. Sedation score (awake 0 to unrousable 4) was also recorded, Analgesia satisfaction score (nil 0 to excellent 4) obtained from the patient on discharge. Results: Sedation scores were similar in both groups excep t in the first postoperative hour, when it was higher in the Iso group . The VAS at rest (15.4 +/- 18.6 vs 29.7 +/- 19.8 mm, P = 0.0001) and nalbuphine requirements (0.13 +/- 0.35 vs 0.70 +/- 0.80 doses, P = 0.0 04) were lower in the iso group during the first six hours, although e mesis was more frequent than in P (60 vs 25%; P = 0.03), The incidence of analgesia satisfaction score (greater than or equal to 3) was simi lar between the two groups (P: 95; Iso: 75%). Conclusion: These result s suggested that isoflurane anaesthesia provides better analgesia than propofol anaesthesia in the first six hours after abdominoplasty.