HEMOGLOBINS IN TOGOLESE NEWBORNS - HB-S, HB-C, HB-BARTS, AND ALPHA-GLOBIN GENE STATUS

Citation
Ay. Segbena et al., HEMOGLOBINS IN TOGOLESE NEWBORNS - HB-S, HB-C, HB-BARTS, AND ALPHA-GLOBIN GENE STATUS, American journal of hematology, 59(3), 1998, pp. 208-213
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology
ISSN journal
0361-8609
Volume
59
Issue
3
Year of publication
1998
Pages
208 - 213
Database
ISI
SICI code
0361-8609(1998)59:3<208:HITN-H>2.0.ZU;2-O
Abstract
The gene frequency of the most important hemoglobin (Hb) abnormalities is reported in a population of 171 Togolese newborns, Hb phenotypes, hematological parameters, and the more frequently described alpha-gene deletions were analyzed, Structural abnormalities of beta-globin were observed in 35.7% of the children with a gene frequency of 0.105 for beta(s) and 0.091 for beta(C). The frequency of the different a-globin genotypes was alpha alpha/ = 0.71, -alpha/ = 0.28, and alpha alpha al pha/ = 0.01, All of the individuals homozygous for the -alpha/ genotyp es, and most of the heterozygous individuals, carried Hb Bart's. Withi n the alpha alpha/alpha alpha and the -alpha/alpha alpha groups, sever al individuals with or without Hb Bart's were found; they did not diff er from the others by their red blood cell (RBC) parameters but by the ir levels of fetal hemoglobin (Hb F). The African alpha 2 polymorphism marker, characterized by the replacement of G by TCGGCCC at position 7238 (EMBL HSHBA4, 1993) and of T 7174 by G, was found in 21 newborns, The mean value of Hb F was calculated for each genotype, the mean (G) gamma percentage was 69.4 +/- 4.0%, and the gene frequency of the (A)g amma(T)marker was 0.10; this marker was linked to the normal beta-glob in cluster, (C) 1998 Wiley-Liss, Inc.