F. Hong et al., SYNTHESIS OF ENANTIOMERIC SELECTIVE ALPHA(1)-ACID GLYCOPROTEIN (AGP)-BONDED CAPILLARY AND ITS APPLICATION IN CAPILLARY-ELECTROPHORESIS, Analytica chimica acta, 373(2-3), 1998, pp. 207-212
alpha(1)-Acid glycoprotein (AGP) was bonded to a fused silica capillar
y using 3-(2,3-oxopropoxypropyl, trimethylsilane as bridging reagent.
The capillary can be used for the direct enantiomeric separation of so
me basic pharmaceuticals in capillary zone electrophoresis. The relate
d operation parameters such as pH, salt concentration, organic modifie
rs in the buffer have been studied. It is demonstrated that an AGP-bon
ded capillary could be used in the different buffer solutions and unde
r operation conditions in capillary electrophoresis with good stabilit
y. (C) 1998 Elsevier Science B.V. All rights reserved.