SYNTHESIS OF ENANTIOMERIC SELECTIVE ALPHA(1)-ACID GLYCOPROTEIN (AGP)-BONDED CAPILLARY AND ITS APPLICATION IN CAPILLARY-ELECTROPHORESIS

Citation
F. Hong et al., SYNTHESIS OF ENANTIOMERIC SELECTIVE ALPHA(1)-ACID GLYCOPROTEIN (AGP)-BONDED CAPILLARY AND ITS APPLICATION IN CAPILLARY-ELECTROPHORESIS, Analytica chimica acta, 373(2-3), 1998, pp. 207-212
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Analytical
Journal title
ISSN journal
0003-2670
Volume
373
Issue
2-3
Year of publication
1998
Pages
207 - 212
Database
ISI
SICI code
0003-2670(1998)373:2-3<207:SOESAG>2.0.ZU;2-T
Abstract
alpha(1)-Acid glycoprotein (AGP) was bonded to a fused silica capillar y using 3-(2,3-oxopropoxypropyl, trimethylsilane as bridging reagent. The capillary can be used for the direct enantiomeric separation of so me basic pharmaceuticals in capillary zone electrophoresis. The relate d operation parameters such as pH, salt concentration, organic modifie rs in the buffer have been studied. It is demonstrated that an AGP-bon ded capillary could be used in the different buffer solutions and unde r operation conditions in capillary electrophoresis with good stabilit y. (C) 1998 Elsevier Science B.V. All rights reserved.