DETERMINATION OF BENZYDAMINE HYDROCHLORIDE IN SERUM AND URINE BY USING A BENZYDAMINE ION-SELECTIVE PIEZOELECTRIC SENSOR

Citation
Wf. Li et al., DETERMINATION OF BENZYDAMINE HYDROCHLORIDE IN SERUM AND URINE BY USING A BENZYDAMINE ION-SELECTIVE PIEZOELECTRIC SENSOR, Analytical sciences, 14(5), 1998, pp. 955-960
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Analytical
Journal title
ISSN journal
0910-6340
Volume
14
Issue
5
Year of publication
1998
Pages
955 - 960
Database
ISI
SICI code
0910-6340(1998)14:5<955:DOBHIS>2.0.ZU;2-N
Abstract
An ion-selective piezoelectric sensor (ISP) was developed for the rapi d determination of benzydamine hydrochloride in serum and urine. The I SP device was fabricated by coating a PVC membrane containing benzydam ine phosphotungstate on one electrode of a thickness-shear mode piezoe lectric quartz crystal. The selective adsorption of benzydamine ion ac ross the membrane caused a decrease in the oscillating frequency; also the logarithm of the frequency shift has a linear relation to the log arithm of the concentration of benzydamine over the ranges 2x10(-7) - 8x10(-3) M with a detection limit of 2.0x10(-7) M at pH 7.0. Influenci ng factors were investigated and optimized. The results for real sampl es obtained by the proposed method were in agreement with those by the conventional non-aqueous titrimetric method.