LIVER-CIRRHOSIS AND THE RISK OF PRIMARY LIVER-CANCER

Citation
C. Lavecchia et al., LIVER-CIRRHOSIS AND THE RISK OF PRIMARY LIVER-CANCER, European journal of cancer prevention, 7(4), 1998, pp. 315-320
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
ISSN journal
0959-8278
Volume
7
Issue
4
Year of publication
1998
Pages
315 - 320
Database
ISI
SICI code
0959-8278(1998)7:4<315:LATROP>2.0.ZU;2-U
Abstract
The relationship between liver cirrhosis and hepatocellular carcinoma is recognized, but quantification of risk is still uncertain. Therefor e, we analysed data from a case-control study conducted in Italy betwe en 1984 and 1997 on 499 cases of incident, histologically confirmed he patocellular carcinoma and 1,552 controls in hospital with acute, non- neoplastic disease. Overall, 87 (17.4%) cases vs 10 (0.6%) controls re ported clinical history of liver cirrhosis, The corresponding odds rat io (OR) was 27.5 (95% confidence interval (CI), 14.3-15.2) after allow ance for sociodemographic factors, and 16.2 (95% CI, 7.9-32.9) after s imultaneous allowance for all identified confounding factors, includin g alcohol consumption and clinical history of hepatitis, The associati on was of similar magnitude for subjects whose cirrhosis was diagnosed < 55 years (OR = 14.8) or at age 55 or over (OR = 20.0), and the mult ivariate OR was 33.7 < 5 years after diagnosis of cirrhosis, 37.3 betw een 5 and 9 years, and 7.6 (95% to 2.7-21.3) greater than or equal to 10 years since diagnosis of cirrhosis, The association was stronger in males (OR = 23.4) than in females (OR = 5,9), similar in various age groups, and somewhat stronger in more educated subjects (OR = 53.7), w ith history of hepatitis (OR = 33.1), reporting heavy alcohol consumpt ion (OR = 24.9) or high body mass index (OR = 58.1), although the inte raction term was significant only for sex. In terms of population attr ibutable risk, 17% of hepatocellular carcinomas in this population can be attributed to clinical history of liver cirrhosis, (C) 1998 Lippin cott Williams & Wilkins.