I. Davidkin et M. Valle, VACCINE-INDUCED MEASLES-VIRUS ANTIBODIES AFTER 2 DOSES OF COMBINED MEASLES, MUMPS AND RUBELLA VACCINE - A 12-YEAR FOLLOW-UP IN 2 COHORTS, Vaccine, 16(20), 1998, pp. 2052-2057
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Veterinary Sciences",Immunology,"Medicine, Research & Experimental
In Finland, a two-nose vaccination programme against measles, mumps an
d rubella (MMR) was begun in 1982. The programme with high coverage (9
7-98%) has eliminated these three diseases from Finland. The aim of th
e present study was to follow up the kinetics of measles virus antibod
ies in MMR vaccinated cohorts. We have followed the kinetics of measle
s virus antibody levels induced by vaccination in the same individuals
immunized with their first MMR vaccine in 1982. After 12 years 80% of
the original children remained available for sampling. Antibodies to
measles virus were measured by haemagglutination inhibition (HI) and p
laque reduction neutralization (NT) techniques. The primary nose induc
ed 99.4% seroconversion for measles with a geometric mean HI antibody
the (GMT) of 1/269 (+/-219), equivalent to 4303 mIU (milli-Internation
al Units) ml(-1) in group A. The 12-year follow-up specimens showed a
measles seropositivity rate of 100% as assayed with the HI and NT test
s with a mean HI antibody titre of 1/39 (+/-54), equivalent to 624 mIU
ml(-1). The vaccination-induced measles virus antibodies decline in t
he absence of natural booster infections. It is important to follow ho
w long the protection achieved by the present vaccine programme will l
ast after elimination of indigenous measles. (C) 1998 Elsevier Science
Ltd. All rights reserved.