VACCINE-INDUCED MEASLES-VIRUS ANTIBODIES AFTER 2 DOSES OF COMBINED MEASLES, MUMPS AND RUBELLA VACCINE - A 12-YEAR FOLLOW-UP IN 2 COHORTS

Citation
I. Davidkin et M. Valle, VACCINE-INDUCED MEASLES-VIRUS ANTIBODIES AFTER 2 DOSES OF COMBINED MEASLES, MUMPS AND RUBELLA VACCINE - A 12-YEAR FOLLOW-UP IN 2 COHORTS, Vaccine, 16(20), 1998, pp. 2052-2057
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Veterinary Sciences",Immunology,"Medicine, Research & Experimental
Journal title
ISSN journal
0264-410X
Volume
16
Issue
20
Year of publication
1998
Pages
2052 - 2057
Database
ISI
SICI code
0264-410X(1998)16:20<2052:VMAA2D>2.0.ZU;2-G
Abstract
In Finland, a two-nose vaccination programme against measles, mumps an d rubella (MMR) was begun in 1982. The programme with high coverage (9 7-98%) has eliminated these three diseases from Finland. The aim of th e present study was to follow up the kinetics of measles virus antibod ies in MMR vaccinated cohorts. We have followed the kinetics of measle s virus antibody levels induced by vaccination in the same individuals immunized with their first MMR vaccine in 1982. After 12 years 80% of the original children remained available for sampling. Antibodies to measles virus were measured by haemagglutination inhibition (HI) and p laque reduction neutralization (NT) techniques. The primary nose induc ed 99.4% seroconversion for measles with a geometric mean HI antibody the (GMT) of 1/269 (+/-219), equivalent to 4303 mIU (milli-Internation al Units) ml(-1) in group A. The 12-year follow-up specimens showed a measles seropositivity rate of 100% as assayed with the HI and NT test s with a mean HI antibody titre of 1/39 (+/-54), equivalent to 624 mIU ml(-1). The vaccination-induced measles virus antibodies decline in t he absence of natural booster infections. It is important to follow ho w long the protection achieved by the present vaccine programme will l ast after elimination of indigenous measles. (C) 1998 Elsevier Science Ltd. All rights reserved.