MORPHOMETRIC ANALYSIS OF PANCREATIC-CARCINOMA BY COMPUTER-ASSISTED IMAGE-ANALYSIS

Citation
A. Wolnicka et al., MORPHOMETRIC ANALYSIS OF PANCREATIC-CARCINOMA BY COMPUTER-ASSISTED IMAGE-ANALYSIS, Folia Biologica, 46(1-2), 1998, pp. 7-15
Citations number
42
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology,Zoology
Journal title
ISSN journal
0015-5497
Volume
46
Issue
1-2
Year of publication
1998
Pages
7 - 15
Database
ISI
SICI code
0015-5497(1998)46:1-2<7:MAOPBC>2.0.ZU;2-8
Abstract
This report describes the results of applying the interactive image an alysis system for the measurement of some cytological parameters corre sponding to features of adenocarcinoma of the pancreas. The present ex periments were carried out by means of the digital cell image analysis of haematoxilyn and eosin stained archival standard glass slides of c ancer bearing and healthy patients. Four different parameters describi ng the morphology of nuclei and nucleoli were selected to quantitate t he differences between control and malignant tissues: area, perimeter, elongation, and extension. The parameters that showed the greatest di fferences between cancerous and normal pancreas were: area and elongat ion in the case of nuclei as well as area and perimeter for nucleoli. However. the results of this study suggest that none of the four analy sed parameters can be selected alone to discriminate neoplastic from n ormal cells, but could be used all together in diagnosis of pancreatic cancer.