Introduction: The prostacyclin analog Iloprost has been shown to improve sp
lanchnic perfusion in endotoxin mediated septic shock. Aim of this study wa
s to evaluate the therapeutic effect of Iloprost on splanchnic oxygen trans
port and - utilization in a long-term model of septic shock in pigs.
Methods: In a long term model of hyperdynamic porcine endotoxin shock (8 ng
/kg min) th pCO(2) gap was determined by tonometry and indirect calorimetry
was performed. Further macrohemodynamic monitoring and hepatic blood flow
were assessed via a COLD catheter and doppler ultrsound flow probes on hepa
tic artery and poral vein.
Results and Conclusion: Treatment with the PGI(2) analogue Iloprost in a cl
inically relevant dosage exerted no significant effect on intestinal perfus
ion. However,Iloprost lead to an improved intestinal energy balance, as ind
icated by the pCO(2)-gap. Furthermore, a significant improvement of the cyt
osolic redox potential (lactat-pyruvate-ratio) was observed which could be
interpreted as an improvement of intestinal oxygen supply.