Effect of iloprost on intestinal perfusion and energy balance in porcine hyperdynamic septic shock

Citation
C. Zulke et al., Effect of iloprost on intestinal perfusion and energy balance in porcine hyperdynamic septic shock, LANG ARCH S, 1999, pp. 573-575
Citations number
5
Language
TEDESCO
art.tipo
Article
Categorie Soggetti
Surgery
Journal title
LANGENBECKS ARCHIVES OF SURGERY
ISSN journal
1435-2443 → ACNP
Year of publication
1999
Supplement
1
Pages
573 - 575
Database
ISI
SICI code
1435-2443(1999):<573:EOIOIP>2.0.ZU;2-4
Abstract
Introduction: The prostacyclin analog Iloprost has been shown to improve sp lanchnic perfusion in endotoxin mediated septic shock. Aim of this study wa s to evaluate the therapeutic effect of Iloprost on splanchnic oxygen trans port and - utilization in a long-term model of septic shock in pigs. Methods: In a long term model of hyperdynamic porcine endotoxin shock (8 ng /kg min) th pCO(2) gap was determined by tonometry and indirect calorimetry was performed. Further macrohemodynamic monitoring and hepatic blood flow were assessed via a COLD catheter and doppler ultrsound flow probes on hepa tic artery and poral vein. Results and Conclusion: Treatment with the PGI(2) analogue Iloprost in a cl inically relevant dosage exerted no significant effect on intestinal perfus ion. However,Iloprost lead to an improved intestinal energy balance, as ind icated by the pCO(2)-gap. Furthermore, a significant improvement of the cyt osolic redox potential (lactat-pyruvate-ratio) was observed which could be interpreted as an improvement of intestinal oxygen supply.