Prediction of severe and septic courses of acute pancreatitis by noninvasive intramucosal PH-measurements of the sigma

Citation
J. Werner et al., Prediction of severe and septic courses of acute pancreatitis by noninvasive intramucosal PH-measurements of the sigma, LANG ARCH S, 1999, pp. 45-49
Citations number
9
Language
TEDESCO
art.tipo
Article
Categorie Soggetti
Surgery
Journal title
LANGENBECKS ARCHIVES OF SURGERY
ISSN journal
1435-2443 → ACNP
Year of publication
1999
Supplement
1
Pages
45 - 49
Database
ISI
SICI code
1435-2443(1999):<45:POSASC>2.0.ZU;2-3
Abstract
Background: The prognosis of acute pancreatitis is mainly dependent on sept ic complications. Sepsis is characterized by intestinal ischemia, and subse quent mucosal barrier failure and bacterial translocation. Unfortunately, a predictor of severe fatal disease does not exist. Methods and results: Decreased intramucosal pH of the sigma assessed by a n oninvasive invasive sigmoid catheter postively predicted severe courses of acute pancreatitis in rats. The reduction of pHi is the consequence of decr eased mucosal perfusion and can be observed long before failure of the muco sal barrier, bacterial translocation and sepsis. Conclusion: As pHi-measurements are simple and noninvasive, clinical evalua tion should br: performed in humans with acute pancreatitis.