Arterial aneurysms in patients infected with human immunodeficiency virus:A distinct clinicopathology entity?

Citation
R. Nair et al., Arterial aneurysms in patients infected with human immunodeficiency virus:A distinct clinicopathology entity?, J VASC SURG, 29(4), 1999, pp. 600-607
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
JOURNAL OF VASCULAR SURGERY
ISSN journal
0741-5214 → ACNP
Volume
29
Issue
4
Year of publication
1999
Pages
600 - 607
Database
ISI
SICI code
0741-5214(199904)29:4<600:AAIPIW>2.0.ZU;2-Z
Abstract
Arterial aneurysms have only recently been associated with the human immuno deficiency virus (HIV). The clinical and pathological features of 10 HIV-po sitive patients with arterial aneurysms were retrospectively evaluated. The se aneurysms were unusual in that they affected young black patients, occur red in atypical sites, and tended toward multiplicity Surgery was performed in eight-patients. Acute and chronic inflammatory changes were revealed by means of histologic examination of the aneurysm walls, with occlusion of t he vasa vasora by inflammatory infiltrate or edema being a prominent featur e. Culture of the aneurysm wall or thrombus yielded positive results in two patients; The association between HIV and aneurysms may be coincidental, c aused by direct viral action or by bacterial infection resulting from immun osuppression. Implications for therapy are discussed, and the need for furt her study is highlighted.