Dioxygen-activating bio-inorganic model complexes

Citation
Hc. Liang et al., Dioxygen-activating bio-inorganic model complexes, CURR OP C B, 3(2), 1999, pp. 168-175
Citations number
88
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CURRENT OPINION IN CHEMICAL BIOLOGY
ISSN journal
1367-5931 → ACNP
Volume
3
Issue
2
Year of publication
1999
Pages
168 - 175
Database
ISI
SICI code
1367-5931(199904)3:2<168:DBMC>2.0.ZU;2-W
Abstract
The study of model compounds continues to significantly contribute to our u nderstanding of the role of transition metals at the active sites of enzyme s. Recent advances in the field include the use of mimics for enzymes that activate dioxygen, as dioxygen is not only manipulated in nature but also h as industrial significance in metal-catalyzed oxidations of organics. Coppe r, nonheme and heme iron coordination complexes have been used to mimic rev ersible dioxygen-binding by the three classes of blood-oxygen carriers - he mocyanin, hemerythrin and hemoglobin/myoglobin - while functional mimics of oxygenases and oxidases with copper and iron have also provided key insigh ts into important dioxygen activation processes.