Effect of Lp(a) on the early functional and structural changes of atherosclerosis

Citation
Ot. Raitakari et al., Effect of Lp(a) on the early functional and structural changes of atherosclerosis, ART THROM V, 19(4), 1999, pp. 990-995
Citations number
60
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
ISSN journal
1079-5642 → ACNP
Volume
19
Issue
4
Year of publication
1999
Pages
990 - 995
Database
ISI
SICI code
1079-5642(199904)19:4<990:EOLOTE>2.0.ZU;2-O
Abstract
Epidemiologic studies have shown a significant, relationship between elevat ed plasma levels of Lp(a) and increased risk of cardiovascular events; howe ver, the mechanisms by which elevated Lp(a) levels produce this increased r isk are not known. To test the hypothesis that high Lp(a) levels might cont ribute to the development of subclinical atherosclerosis, we examined the i nfluence of Lp(a) levels on early functional and structural atherosclerotic vascular changes, mow-mediated (endothelium-dependent) and nitrate-mediate d (smooth muscle-dependent) arterial dilations were measured by high-resolu tion ultrasound in 241 normal healthy subjects (aged 15 to 69 years; 116 me n). In addition, carotid artery intima-media thickness was measured by ultr asound in 71 subjects. Plasma Lp(a) was measured using a 2-sided immunoradi ometric assay (cohort median, 10 mg/dL; interquartile range, 3.9 to 24.4 mg /dL). In these subjects, there were no significant relationships between Lp (a) and arterial endothelial function, smooth muscle responses, or carotid wall thickness (P>0.25). By contrast, other Lipid risk factors, such as LDL -cholesterol and LDL-cholesterol/HDL-cholesterol ratio, were significantly correlated with abnormal arterial function and structure (P less than or eq ual to 0.01). These data suggest that elevated Lp(a) levels do not confer c ardiovascular risk by contributing to the early functional or structural ch anges of atherosclerosis.