Arterial endothelial dysfunction related to passive smoking is potentiallyreversible in healthy young adults

Raitakari, OT Adams, MR McCredie, RJ Griffiths, KA Celermajer, DS

Ot. Raitakari et al., Arterial endothelial dysfunction related to passive smoking is potentiallyreversible in healthy young adults, ANN INT MED, 130(7), 1999, pp. 578-581

19

INGLESE

Article

General & Internal Medicine","Medical Research General Topics

ANNALS OF INTERNAL MEDICINE

0003-4819 → ACNP

130

7

1999

578 - 581

ISI

0003-4819(19990406)130:7<578:AEDRTP>2.0.ZU;2-J

Background: Passive smoking is associated with early arterial damage, but t he potential for reversibility of this damage is unknown. objective: To assess the reversibility of arterial endothelial dysfunction, a key marker of early atherosclerosis. Design: Cross-sectional study. Setting: Academic medical center. Participants: 60 healthy persons 15 to 39 years of age: 20 with no exposure to active or passive smoking, 20 nonsmoking passive smokers (exposure to e nvironmental tobacco smoke for greater than or equal to 1 hour per day for greater than or equal to 2 years), and 20 former passive smokers. Measurements: Arterial endothelial function measured by noninvasive ultraso nography. Results: Endothelium-dependent dilatation was significantly better in forme r passive smokers (5.1% +/- 4.1% [range, -1.2% to 15.6%]) than in current p assive smokers (2.3% +/- 2.1% [range, -0.2% to 6.7%]) (P = 0.01), although both groups were significantly impaired compared with nonsmoking controls ( 8.9% +/- 3.2% [range, 2.1% to 16.7%]) (P less than or equal to 0.01 for bot h comparisons). Conclusions: In healthy young adults, arterial endothelial dysfunction rela ted to passive smoking seems to be partially reversible.