Arterial endothelial dysfunction related to passive smoking is potentiallyreversible in healthy young adults

Citation
Ot. Raitakari et al., Arterial endothelial dysfunction related to passive smoking is potentiallyreversible in healthy young adults, ANN INT MED, 130(7), 1999, pp. 578-581
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
ANNALS OF INTERNAL MEDICINE
ISSN journal
0003-4819 → ACNP
Volume
130
Issue
7
Year of publication
1999
Pages
578 - 581
Database
ISI
SICI code
0003-4819(19990406)130:7<578:AEDRTP>2.0.ZU;2-J
Abstract
Background: Passive smoking is associated with early arterial damage, but t he potential for reversibility of this damage is unknown. objective: To assess the reversibility of arterial endothelial dysfunction, a key marker of early atherosclerosis. Design: Cross-sectional study. Setting: Academic medical center. Participants: 60 healthy persons 15 to 39 years of age: 20 with no exposure to active or passive smoking, 20 nonsmoking passive smokers (exposure to e nvironmental tobacco smoke for greater than or equal to 1 hour per day for greater than or equal to 2 years), and 20 former passive smokers. Measurements: Arterial endothelial function measured by noninvasive ultraso nography. Results: Endothelium-dependent dilatation was significantly better in forme r passive smokers (5.1% +/- 4.1% [range, -1.2% to 15.6%]) than in current p assive smokers (2.3% +/- 2.1% [range, -0.2% to 6.7%]) (P = 0.01), although both groups were significantly impaired compared with nonsmoking controls ( 8.9% +/- 3.2% [range, 2.1% to 16.7%]) (P less than or equal to 0.01 for bot h comparisons). Conclusions: In healthy young adults, arterial endothelial dysfunction rela ted to passive smoking seems to be partially reversible.