Effect of calorie restriction on in vivo glucose metabolism by individual tissues in rats

Citation
Tj. Wetter et al., Effect of calorie restriction on in vivo glucose metabolism by individual tissues in rats, AM J P-ENDO, 39(4), 1999, pp. E728-E738
Citations number
45
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Endocrinology, Nutrition & Metabolism
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
ISSN journal
0193-1849 → ACNP
Volume
39
Issue
4
Year of publication
1999
Pages
E728 - E738
Database
ISI
SICI code
0193-1849(199904)39:4<E728:EOCROI>2.0.ZU;2-6
Abstract
We evaluated the effects of 8 mo of calorie restriction [CR: 60% of ad libi tum (AL) food intake] on glucose uptake by 14 tissues in unanesthetized, ad ult (12 mo) F344 x BN rats. Glucose metabolism was assessed by the 2-[H-3]d eoxyglucose tracer technique at 1500 or 2100. Despite an similar to 60% dec line in insulinemia with CR, plasma 2-[H-3]deoxyglucose clearance for CR wa s greater than for AL at both times. A small, CR-related decrease in glucos e metabolic index (R-g') occurred only at 1500 in the spleen and heart, and this decrease was reversed at 2100. In some tissues (cerebellum, lung, kid ney, soleus, and diaphragm), R-g' was unaffected by diet, regardless of tim e. In the other tissues (brown fat, 3 white fat pads, epitrochlearis, plant aris, and gastrocnemius), R-g' was higher or tended to be higher for CR vs. AL at one or both times. These findings indicate that 8 mo of CR did not c ause a continuous reduction in in vivo glucose uptake by any tissue studied , and, in several insulin-sensitive tissues, glucose uptake was at times gr eater for CR vs. AL rats.