ELEVATION OF PLASMA ADENOSINE LEVELS MAY ATTENUATE THE SEVERITY OF CHRONIC HEART-FAILURE

Citation
M. Kitakaze et al., ELEVATION OF PLASMA ADENOSINE LEVELS MAY ATTENUATE THE SEVERITY OF CHRONIC HEART-FAILURE, Cardiovascular drugs and therapy, 12(3), 1998, pp. 307-309
Citations number
9
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy","Cardiac & Cardiovascular System
Journal title
ISSN journal
0920-3206
Volume
12
Issue
3
Year of publication
1998
Pages
307 - 309
Database
ISI
SICI code
0920-3206(1998)12:3<307:EOPALM>2.0.ZU;2-8
Abstract
Adenosine is known to be an endogenous cardioprotective substance. Sin ce we have reported that adenosine levels increase in patients with ch ronic heart failure, me tested whether further elevation of the adenos ine levels due to dipyridamole or dilazep for 6 months modulates the p athophysiology of chronic heart failure. In patients with chronic hear t failure, either dipyridamole (300 mg/d n = 17) or dilazep (300 mg/d n = 5) were administered for 6 months. Twenty-two patients (mean +/- S E age 58 +/- 4 years old) attending a specialized chronic heart failur e (CHF) clinic over 6 months and judged as in New York Heart Associati on (NYHA) function class II or III were examined. The other drugs used for the treatment of CHF were not altered during the study. There wer e 5 patients with CHF caused by ischemic heart diseases, and 17 patien ts with either valvular heart diseases or dilated cardiomyopathy. We f ound that increases in the plasma adenosine levels (202 +/- 34 and 372 +/- 74) nmol/L before and after dipyridamole administration, P < 0.00 5 ameliorate the severity of CHF (NYHA: 2.1 +/- 0.5 to 1.7 +/- 0.2). B oth ejection fraction and maximal oxygen consumption increased. These improvements in the severity of chronic heart failure returned to base line levels 6 months after discontinuation of dipyridamole. Comparable results were obtained in the dilazep protocol. We suggest that the el evation of plasma adenosine levels improves the pathophysiology of CHF .