THE EFFECT OF HEALING ESOPHAGITIS ON ESOPHAGEAL MOTOR FUNCTION AS DETERMINED BY ESOPHAGEAL SCINTIGRAPHY AND AMBULATORY ESOPHAGEAL MOTILITY PH MONITORING

Citation
Ni. Mcdougall et al., THE EFFECT OF HEALING ESOPHAGITIS ON ESOPHAGEAL MOTOR FUNCTION AS DETERMINED BY ESOPHAGEAL SCINTIGRAPHY AND AMBULATORY ESOPHAGEAL MOTILITY PH MONITORING, Alimentary pharmacology & therapeutics, 12(9), 1998, pp. 899-907
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy","Gastroenterology & Hepatology
ISSN journal
0269-2813
Volume
12
Issue
9
Year of publication
1998
Pages
899 - 907
Database
ISI
SICI code
0269-2813(1998)12:9<899:TEOHEO>2.0.ZU;2-P
Abstract
Background: Oesophagitis has been shown by standard manometry to be as sociated with impaired oesophageal motility, but it remains unclear if this abnormality improves with healing of oesophagitis, Aim: To deter mine if healing of oesophagitis improves oesophageal motility using so lid bolus oesophageal transit scintigraphy and combined ambulatory oes ophageal motility/pH monitoring. Methods: Patients with grade II-Ill o esophagitis underwent ambulatory motility/pH monitoring (using a Konig sberg catheter with four pressure transducers at 5 cm intervals) and s olid bolus scintigraphy before and after treatment with omeprazole 20 mg b.d. for 8-14 weeks. Results: Three (11%) of the 28 patients failed to heal, Initial scintigraphy was abnormal in 18 (67%) of 27 patients (one refused scintigraphy), Twenty-three of the 25 healed patients ha d repeat studies showing no significant change in the number which wer e abnormal (16 (64%), P = 1.0) or the overall oesophageal transit time (P = 0.65). Due to intolerance of the technique, only 11 patients had ambulatory motility/pH performed both before and after healing, givin g the study 90% power to detect a 5 mmHg increase in peristaltic ampli tude. No significant improvement was seen in any motility or pH parame ter after healing of oesophagitis. Conclusion: Analysis of oesophageal motility showed no improvement in peristaltic activity after healing of oesophagitis, suggesting that the abnormal motility is either a pri mary disorder or an irreversible consequence of mucosal damage.