HELICOBACTER-PYLORI ERADICATION AND ULCER HEALING WITH DAILY LANSOPRAZOLE, PLUS 1 OR 2 WEEKS CO-THERAPY WITH AMOXICILLIN AND CLARITHROMYCIN

Citation
Ja. Louw et al., HELICOBACTER-PYLORI ERADICATION AND ULCER HEALING WITH DAILY LANSOPRAZOLE, PLUS 1 OR 2 WEEKS CO-THERAPY WITH AMOXICILLIN AND CLARITHROMYCIN, Alimentary pharmacology & therapeutics, 12(9), 1998, pp. 881-885
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy","Gastroenterology & Hepatology
ISSN journal
0269-2813
Volume
12
Issue
9
Year of publication
1998
Pages
881 - 885
Database
ISI
SICI code
0269-2813(1998)12:9<881:HEAUHW>2.0.ZU;2-X
Abstract
Background: Proton pump inhibitor based combination therapy is one sta ndard strategy for Helicobacter pylori eradication, Aim: To compare th e eradication and duodenal ulcer healing efficacy of two 2-week, singl e dose, lansoprazole based combination therapies. Methods: Healthy adu lt patients with endoscopically confirmed, H. pylori associated duoden al ulcer disease (3 mm > ulcer < 20 mm) were eligible for the study. A ll patients received a 14 day course of lansoprazole 30 mg o.m., and w ere randomized to receive either 7 or 14 days of amoxycillin 1 g b.d. and clarithromycin 500 mg b.d. Patients were endoscoped at entry and 1 4-17 days later, Symptomatic, unhealed patients received a further 14 days of therapy with lansoprazole SO mg o.m. Eradication was confirmed a minimum of 28 days after cessation of all therapy by urease reactio n and histological assessment of gastric body and antral biopsies (thr ee biopsies each site). Results: Sixty-two patients were randomized to a treatment arm, of which 58 could be included in an intention-to-tre at and key-point-available analysis. H. pylori eradication rates were identical, at 93% (95% CI: 73-98% (1 week), 78-99% (2 week)). In the c ombined group, all but 13 ulcers were healed at 2 weeks; six required further therapy because of symptoms, while six of the seven asymptomat ic patients went on to heal. Conclusion: An eradication regimen, based on a 2-week course of single dose lansoprazole with 1 week of antibio tic co-therapy, is effective in eradicating H. pylori, while the 2 wee ks of acid suppression is usually effective in duodenal ulcer healing.