PANTOPRAZOLE 20 MG IS EFFECTIVE FOR RELIEF OF SYMPTOMS AND HEALING OFLESIONS IN MILD REFLUX ESOPHAGITIS

Citation
A. Dettmer et al., PANTOPRAZOLE 20 MG IS EFFECTIVE FOR RELIEF OF SYMPTOMS AND HEALING OFLESIONS IN MILD REFLUX ESOPHAGITIS, Alimentary pharmacology & therapeutics, 12(9), 1998, pp. 865-872
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy","Gastroenterology & Hepatology
ISSN journal
0269-2813
Volume
12
Issue
9
Year of publication
1998
Pages
865 - 872
Database
ISI
SICI code
0269-2813(1998)12:9<865:P2MIEF>2.0.ZU;2-U
Abstract
Aim: To investigate the efficacy of a low dose of pantoprazole, a gast ric proton pump inhibitor, for the relief of symptoms and healing of l esions in mild gastro-oesophageal reflux disease (GERD), and to compar e it with the efficacy of ranitidine. Methods: Patients with endoscopi cally established GERD (Stage I, Savary-Miller classification) were en rolled into a randomized, double-blind, parallel-group and multicentre study (intention-to-treat n = 209, age range 19-82 years). They were treated once daily with oral pantoprazole 20 mg or ranitidine 300 mg, for up to 8 weeks. End-point parameters included relief of symptoms (h eartburn, acid regurgitation, pain on swallowing) and the healing of G ERD lesions. Relief from symptoms was assessed after 2 and 4 weeks, an d endoscopically confirmed healing of lesions after 4 and 8 weeks. Res ults: The proportion of patients reporting complete relief from sympto ms after 2 weeks was greater in the pantoprazole than in the ranitidin e group (69 vs. 48%, P < 0.01), with further improvements seen in the pantoprazole group after 4 weeks (80 vs. 65%, P < 0.05, Cochran-Mantel /Haenszel test). Healing of lesions was confirmed in 70/87 (80%) patie nts after 4 weeks (pantoprazole group), as compared with 55/86 (64%) p atients (ranitidine group) (P < 0.05, per protocol population); after 8 weeks the respective results were 78/87 (90%) and 63/86 (73%) patien ts (P < 0.01). Both study medications were well tolerated. Conclusion: Low-dose pantoprazole (20 mg) is clinically superior to ranitidine (3 00 mg) in providing fast relief from symptoms and healing of lesions i n patients with mild GERD.