FERRIC TRIMALTOL CORRECTS IRON-DEFICIENCY ANEMIA IN PATIENTS INTOLERANT OF IRON

Citation
Rsj. Harvey et al., FERRIC TRIMALTOL CORRECTS IRON-DEFICIENCY ANEMIA IN PATIENTS INTOLERANT OF IRON, Alimentary pharmacology & therapeutics, 12(9), 1998, pp. 845-848
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy","Gastroenterology & Hepatology
ISSN journal
0269-2813
Volume
12
Issue
9
Year of publication
1998
Pages
845 - 848
Database
ISI
SICI code
0269-2813(1998)12:9<845:FTCIAI>2.0.ZU;2-7
Abstract
Background: Oral iron supplements, which are usually in the form of fe rrous (Fe2+) salts, are toxic to the gastrointestinal mucosa, and so i ntolerance is common, resulting in poor compliance and failure of trea tment. The sugar derivative maltol strongly chelates iron, rendering i t available for absorption and stabilized in the less toxic ferric (Fe 3+) form. Aim: To test whether ferric trimaltol could correct iron def iciency anaemia in patients intolerant of ferrous sulphate, Methods: T wenty-three patients were recruited from gastroenterology clinics, of whom 15 had inflammatory bowel disease, a group often difficult to tre at with oral iron, Patients with iron deficiency anaemia and documente d intolerance to ferrous sulphate were given 3 months of treatment wit h ferric trimaltol. Results: Nineteen of 23 patients completed the tre atment and anaemia was fully corrected in 14 of these, mean haemoglobi n increased from 106 +/- 15 to 126 +/- 16 g/L, and there was a particu larly low incidence of side-effects, Of 11 patients with inflammatory bowel disease who completed the study, nine fully corrected their anae mia. Conclusion: The results demonstrate that in patients intolerant o f ferrous compounds, ferric trimaltol corrects iron deficiency and has a low incidence of side-effects.