NEW INSIGHTS IN THE PHYSIOLOGY AND MOLECULAR-BASIS OF THE INTESTINAL BILE-ACID ABSORPTION

Citation
M. Montagnani et al., NEW INSIGHTS IN THE PHYSIOLOGY AND MOLECULAR-BASIS OF THE INTESTINAL BILE-ACID ABSORPTION, Italian Journal of Gastroenterology and Hepatology, 30(4), 1998, pp. 435-440
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenterology & Hepatology
ISSN journal
1125-8055
Volume
30
Issue
4
Year of publication
1998
Pages
435 - 440
Database
ISI
SICI code
1125-8055(1998)30:4<435:NIITPA>2.0.ZU;2-4
Abstract
Intestinal bile acid absorption is a fundamental step in the enterohep atic circulation and metabolism of these endogenous compounds. The phy siology of the active, sodium coupled transport system for bile acids in the terminal ileum has been extensively studied and characterized S tructure-activity studies have elucidated the requirements for the ile al transport system, and studies with photolabile bile acid derivative s identified the putative ileal bile acid transport proteins. Characte rization of the functional sites of the transport system elucidated so me of the possible mechanisms which allow the interaction of bile acid s and sodium ions with the ileal transporter Considerable progress has been made during recent years, after the ileal apical and cytosolic b ile acid transport proteins have been cloned and characterized. The ro le of point mutations in bile acid malabsorption has been studied, and the knowledge of the amino acid sequence of the transport proteins wi ll be of help in the investigation of the transport mechanisms.