BASAL AND PENTAGASTRIN-STIMULATED ACID-SECRETION IN DUODENAL-ULCER SUBJECTS BEFORE AND AFTER HELICOBACTER-PYLORI ERADICATION - A 12-MONTH FOLLOW-UP-STUDY

Citation
Ja. Louw et al., BASAL AND PENTAGASTRIN-STIMULATED ACID-SECRETION IN DUODENAL-ULCER SUBJECTS BEFORE AND AFTER HELICOBACTER-PYLORI ERADICATION - A 12-MONTH FOLLOW-UP-STUDY, Italian Journal of Gastroenterology and Hepatology, 30(4), 1998, pp. 363-367
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Gastroenterology & Hepatology
ISSN journal
1125-8055
Volume
30
Issue
4
Year of publication
1998
Pages
363 - 367
Database
ISI
SICI code
1125-8055(1998)30:4<363:BAPAID>2.0.ZU;2-8
Abstract
Background The effect of infection by Helicobacter pylori on gastric p hysiology in duodenal ulcer subjects is controversial. There is eviden ce that the infection is associated with abnormalities in gastrin home ostasis. Consistent changes in pentagastrin-stimulated acid secretory status have proved difficult to establish. This may be because patient s have been studied too soon after Helicobacter pylori eradication. Ai ms. To study the immediate and longer term effect of Helicobacter pylo ri eradication on basal and pentagastrin-stimulated acid secretion in duodenal ulcer subjects. Patients and Methods. Patients with active du odenal ulcer disease were studied. Ulcers were healed with sucralfate 2 g bd or ranitidine 300 mg nocte. Helicobacter pylori eradication was attempted with bismuth-based ''Triple Therapy'', and the nine patient s in whom the organism was successfully eradicated were followed and s tudied over the 12-month period Acid secretion was studied at entry (p rior to the initiation of therapy), following healing, following eradi cation and 12 months later Basal, low dose (0.1 mu g/kg) and high dose (6 mu g/kg) pentagastrin-stimulated acid secretion was determined Res ults. Whilst there was a tendency for basal and low dose-stimulated ac id secretion to fall following eradication, in this study only the red uction in high dose-stimulated acid secretion achieved significance fo llowing eradication (entry mean = 59.6 post eradication mean = 49.6, p <0.03). This effect of eradication on high dose pentagastrin-stimulate d acid secretion was also seen at the 12-month study (mean = 48.9, p<0 .02 versus entry). Conclusion. The findings of this study suggests tha t maximally stimulated acid secretion is modestly, albeit significantl y, reduced following Helicobacter pylori eradication and that this eff ect persists.