MAGNETICALLY INDUCED MOTOR EVOKED-POTENTIALS AND H-REFLEX DURING NEMBUTAL AND KETAMINE ANESTHESIA ADMINISTRATION IN RATS

Citation
A. Chiba et al., MAGNETICALLY INDUCED MOTOR EVOKED-POTENTIALS AND H-REFLEX DURING NEMBUTAL AND KETAMINE ANESTHESIA ADMINISTRATION IN RATS, Research communications in molecular pathology and pharmacology, 101(1), 1998, pp. 43-57
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy",Pathology,Biology
ISSN journal
1078-0297
Volume
101
Issue
1
Year of publication
1998
Pages
43 - 57
Database
ISI
SICI code
1078-0297(1998)101:1<43:MIMEAH>2.0.ZU;2-3
Abstract
The effects of nembutal and ketamine anesthesia on motor evoked potent ials (MEPs) and spinal segment reflex (H-response, F and M waves) were investigated in rats by magnetic stimulation. These potentials were g enerated by magnetic stimulation of the motor cortex and the spinal co rd (L4-L5). After application of nembutal, MEP and H-response decrease d in amplitude, eventually disappearing. The amplitudes of F and M wav es increased and persisted at the increased levels during anesthesia. The latencies off and M waves were constant before and after anesthesi a. Following ketamine administration, the threshold, latency and ampli tude of the magnetically induced MEPs, and M, F and H responses were n ot influenced systematically. The results suggested that MEPs and H-re sponse depression and/or disappearance due to synaptic site suppressio n after nembutal anesthesia, and the increase and persistence of incre ased F and M waves amplitudes were all due to the increasing motoneuro n excitability, whereas ketamine did not affect synaptic sites subject ed to magnetic stimulation.