HIGHLY EFFICIENT AND VERSATILE SYNTHESIS OF LIBRARIES OF CONSTRAINED BETA-STRAND MIMETICS

Citation
Co. Ogbu et al., HIGHLY EFFICIENT AND VERSATILE SYNTHESIS OF LIBRARIES OF CONSTRAINED BETA-STRAND MIMETICS, Bioorganic & medicinal chemistry letters, 8(17), 1998, pp. 2321-2326
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
ISSN journal
0960-894X
Volume
8
Issue
17
Year of publication
1998
Pages
2321 - 2326
Database
ISI
SICI code
0960-894X(1998)8:17<2321:HEAVSO>2.0.ZU;2-Q
Abstract
The general approach of using a bicyclic template to produce inhibitor s of the protease superfamily of enzymes has been investigated. The Di els-Alder cycloaddition reaction on solid support has been found to be highly efficient for the synthesis of libraries of compounds that mim ic the beta-strand secondary structure of proteins. Several potent and selective inhibitors of proteases have been discovered. (C) 1998 Else vier Science Ltd. All rights reserved.