DEHYDROEPIANDROSTERONE-SULFATE DEFICIENCY IN CHRONIC-FATIGUE-SYNDROME

Citation
H. Kuratsune et al., DEHYDROEPIANDROSTERONE-SULFATE DEFICIENCY IN CHRONIC-FATIGUE-SYNDROME, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 1(1), 1998, pp. 143-146
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medicine, Research & Experimental
ISSN journal
1107-3756
Volume
1
Issue
1
Year of publication
1998
Pages
143 - 146
Database
ISI
SICI code
1107-3756(1998)1:1<143:DDIC>2.0.ZU;2-N
Abstract
The chronic fatigue syndrome (CFS) is a condition of unknown etiology, characterized by a persistent debilitating fatigue, the muscle-relate d symptoms and the neuropsychiatric symptoms. Recently, it has been re ported that the patients with CFS might have impaired activation of th e hypothalamic-pituitary-adrenal axis, and suggested that a part of th e pathogenesis of CFS might be associated with abnormalities of the en docrine system. Herein, we show that the majority of Japanese patients with CFS had a serum dehydroepiandrosterone sulfate (DHEA-S) deficien cy. Serum DHEA-S is one of the most abundantly produced hormones which is secreted from the adrenal glands, and its physiological function i s thought to be a precursor of sex steroids. DHEA-S has recently been shown to have physiological properties, such as neurosteroids, which a re associated with such psychophysiological phenomena as memory, stres s, anxiety, sleep and depression. Therefore, the deficiency of DHEA-S might be related to the neuropsychiatric symptoms in patients with CFS .