PLASMA-LEVELS OF NATRIURETIC PEPTIDES AND ADRENOMEDULLIN IN ELDERLY HYPERTENSIVE PATIENTS - RELATIONSHIPS TO 24H BLOOD-PRESSURE

Citation
K. Kario et al., PLASMA-LEVELS OF NATRIURETIC PEPTIDES AND ADRENOMEDULLIN IN ELDERLY HYPERTENSIVE PATIENTS - RELATIONSHIPS TO 24H BLOOD-PRESSURE, Journal of hypertension, 16(9), 1998, pp. 1253-1259
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Peripheal Vascular Diseas
Journal title
ISSN journal
0263-6352
Volume
16
Issue
9
Year of publication
1998
Pages
1253 - 1259
Database
ISI
SICI code
0263-6352(1998)16:9<1253:PONPAA>2.0.ZU;2-X
Abstract
Objective The aim of this study was to investigate the relationships b etween levels of natriuretic peptides and adrenomedullin and 24 h bloo d pressure levels in elderly hypertensives. Design and methods We perf ormed both 24 h ambulatory blood pressure monitoring and measurement o f plasma levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and adrenomedullin in 118 asymptomatic hypertensive eld erly (greater than or equal to 60 years old) patients. We classified t he subjects into groups with isolated clinic hypertension (n = 40) and sustained hypertension (n = 78), We also measured the levels of these peptides in 37 elderly normotensive subjects. Results Plasma ANP and BNP levels were slightly increased in patients with isolated clinic hy pertension compared with elderly normotensives. Among the hypertensive s, plasma ANP and BNP levels were more closely related to 24 h blood p ressure levels than to office blood pressure levels. Sustained hyperte nsives showed significantly increased plasma levels of ANP and BNP com pared with isolated clinic hypertensives. while adrenomedullin levels were similar in the two groups. Elderly hypertensives with left ventri cular hypertrophy detected by electrocardiography had significantly hi gher levels of ANP and BNP, and higher BNP/ANP ratios than those witho ut left ventricular hypertrophy, while there was no significant differ ence in adrenomedullin levels between the two groups. Conclusions Our results suggest that measurements of ANP and BNP may be useful in dete cting left ventricular hypertrophy and in differentiating isolated cli nic hypertension from sustained hypertension in elderly hypertensive p atients. J Hypertens 16:1253-1259 (C) 1998 Lippincott Williams & Wilki ns.