COFFEE CONSUMPTION AND RISK OF HOSPITALIZED MISCARRIAGE BEFORE 12 WEEKS OF GESTATION

Citation
F. Parazzini et al., COFFEE CONSUMPTION AND RISK OF HOSPITALIZED MISCARRIAGE BEFORE 12 WEEKS OF GESTATION, Human reproduction (Oxford. Print), 13(8), 1998, pp. 2286-2291
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Reproductive Biology","Obsetric & Gynecology
ISSN journal
0268-1161
Volume
13
Issue
8
Year of publication
1998
Pages
2286 - 2291
Database
ISI
SICI code
0268-1161(1998)13:8<2286:CCAROH>2.0.ZU;2-M
Abstract
In order to analyse the association between drinking coffee in pregnan cy and risk of spontaneous abortion, a case-controlled study was condu cted in Milan, Northern Italy. Cases were 782 women with spontaneous a bortion within the 12th week of gestation. The control group was recru ited from women who gave birth at term (>37 weeks gestation) to health y infants on randomly selected days at the same hospitals where cases had been identified: 1543 controls were interviewed. A total of 561 (7 2%) cases of spontaneous abortion and 877 (57%) controls reported coff ee drinking during the first trimester of the index pregnancy. The cor responding multivariate odds ratios of spontaneous abortion, in compar ison with non-drinkers, were 1.2, 1.8 and 4.0, respectively, for drink ers of 1, 2 or 3, and 4 or more cups of coffee per day. No relationshi p emerged between maternal decaffeinated coffee, tea and cola drinking in pregnancy, as well as paternal coffee consumption, and risk of spo ntaneous abortion. With regard to duration in years of coffee drinking , the estimated multivariate odds ratios of spontaneous abortion were, in comparison with non-coffee drinkers, 1.1 (95% confidence interval (CI) 0.9-1.4) and 1.9 (95 % CI 1.5-2.6) for women reporting a duration of coffee consumption less than or equal to 10 or >10 years. In concl usion, coffee drinking early in pregnancy was associated with an incre ased risk of abortion. This has biological implications, but epidemiol ogical inference on the causality is difficult and still open to debat e.