SELECTIVE PROTECTION OF THE PRIMARY AMINE FUNCTIONS OF LINEAR TETRAAMINES USING THE TRITYL GROUP

Citation
Ke. Krakowiak et Js. Bradshaw, SELECTIVE PROTECTION OF THE PRIMARY AMINE FUNCTIONS OF LINEAR TETRAAMINES USING THE TRITYL GROUP, Synthetic communications, 28(18), 1998, pp. 3451-3459
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
ISSN journal
0039-7911
Volume
28
Issue
18
Year of publication
1998
Pages
3451 - 3459
Database
ISI
SICI code
0039-7911(1998)28:18<3451:SPOTPA>2.0.ZU;2-8
Abstract
Treatment of linear tetraamines 3,6-diaza-1,8-octanediamine (1); 4,7-d iaza-1,10-decanediamine (2); and 4,9-diaza-1,12-dodecanediamine (sperm ine) (3) with equimolar amounts of trityl chloride allowed preparation of the alpha,omega-bistrityl-protected tetraamines 4, 6 and 8 in good to excellent yields. A 2:1 ratio of trityl chloride to tetraamine gav e a tritrityl-substituted by-product. An internal N,N'-ditrityl-substi tuted tetraamine, 5,8-ditrityl-1,5,8,12-tetraazadodecane (10), was als o prepared as a further proof of the structures of the alpha,omega-dit rityl-substituted tetraamines.