ANTIOXIDANT PROPERTIES OF CLOZAPINE AND RELATED NEUROLEPTICS

Citation
A. Dallalibera et al., ANTIOXIDANT PROPERTIES OF CLOZAPINE AND RELATED NEUROLEPTICS, Free radical research, 29(2), 1998, pp. 151-157
Citations number
36
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology
Journal title
ISSN journal
1071-5762
Volume
29
Issue
2
Year of publication
1998
Pages
151 - 157
Database
ISI
SICI code
1071-5762(1998)29:2<151:APOCAR>2.0.ZU;2-E
Abstract
The antioxidant properties of clozapine and other related molecules we re evaluated with the crocin bleaching test both in aqueous and non-aq ueous environment. The tests of microsomal lipid peroxidation and carb onyl formation were also used. In aqueous solution, chlorpromazine and trifluoperazine appear particularly effective in the bleaching of cro cin, while serotonin has an efficacy intermediate between those of phe nothiazines and clozapine. The latter drug, on the other hand, in a no n-aqueous medium shows an antioxidant power comparable to that of buty lated hydroxytoluene, indicating that its antioxidant properties are b etter expressed in a hydrophobic environment of the type present in a biological membrane. In fact, in lipid peroxidation induced in microso mal membranes, clozapine, chlorpromazine, trifluoperazine and serotoni n act as very good antioxidants; at low concentrations, clozapine appe ars to be the most efficient after butylated hydroxytoluene. Similarly , all these compounds markedly inhibit protein carbonyl formation, clo zapine being one of the most efficient. Thus, under different in vitro experimental conditions, the neuroleptic drugs chlorpromazine and tri fluoperazine and the antipsychotic substance clozapine act as very eff ective antioxidants; this property might, at least in part, be respons ible for the physiological and clinical effects observed il vivo.