CALRETININ EXPRESSION AS A CRITICAL COMPONENT IN THE CONTROL OF DENTATE GYRUS LONG-TERM POTENTIATION INDUCTION IN MICE

Citation
H. Gurden et al., CALRETININ EXPRESSION AS A CRITICAL COMPONENT IN THE CONTROL OF DENTATE GYRUS LONG-TERM POTENTIATION INDUCTION IN MICE, European journal of neuroscience, 10(9), 1998, pp. 3029-3033
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences
ISSN journal
0953-816X
Volume
10
Issue
9
Year of publication
1998
Pages
3029 - 3033
Database
ISI
SICI code
0953-816X(1998)10:9<3029:CEAACC>2.0.ZU;2-C
Abstract
We have recently reported that mice homozygous (Cr-/-) for a null muta tion in the calretinin gene have impaired long-term potentiation (LTP) induction in the dentate gyrus (S, Schurmans et al. (1997) Proc. Natl . Acad. Sci. USA, 94, 10415), Here, we investigated dentate LTP induct ion in mice heterozygous (Cr+/-) for the same mutation. Despite the pr esence of calretinin in neurons of these mice, although at reduced lev els as compared with normal mice, LTP induction in dentate gyrus was t otally impaired. Spatial memory and learning were found unaffected in Cr+/- mice, such as in Cr-/- mice. Altogether, our results suggest tha t calretinin is a critical component in the control of dentate synapti c plasticity in mice, and that levels of calretinin higher than those observed in Cr+/- mice are required to induce LTP in this area. The po ssible mechanisms leading to the absence of correlation between gene d osage and biological effects are discussed.