RISK-FACTORS FOR CERVICAL PRESENCE OF HUMAN-PAPILLOMAVIRUS DNA AMONG WOMEN AT RISK FOR HIV-INFECTION

Citation
G. Rezza et al., RISK-FACTORS FOR CERVICAL PRESENCE OF HUMAN-PAPILLOMAVIRUS DNA AMONG WOMEN AT RISK FOR HIV-INFECTION, Epidemiology and infection, 121(1), 1998, pp. 173-177
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Public, Environmental & Occupation Heath","Infectious Diseases
Journal title
ISSN journal
0950-2688
Volume
121
Issue
1
Year of publication
1998
Pages
173 - 177
Database
ISI
SICI code
0950-2688(1998)121:1<173:RFCPOH>2.0.ZU;2-9
Abstract
Risk factors for cervical infection with human papillomavirus (HPV) we re assessed among 236 Italian women at risk for human immunodeficiency virus (HIV) infection (intravenous drug users (IVDU) or sexual partne rs of males at risk for HIV infection). All study participants underwe nt a structured interview, determination of HIV serostatus and detecti on of HPV cervical infection by means of polymerase chain reaction (PC R). Overall, the cervical presence of HPV DNA was ascertained in 86 of these 236 women (36.4 %), while squamous intraepithelial lesions (SIL ) were diagnosed in 57 (24.1 %). HPV-infected and non-infected women d id not differ in age, education and cigarette smoking. A statistically significant trend in the risk of HPV infection with increasing number of lifetime sexual partners was noted (P = 0.01), but such trend was attenuated in multivariate analysis (multiple logistic regression (MLR ) odds ratio (OR) for greater than or equal to 20 partners vs 1 = 1.6, 95 % confidence intervals (CI): 0.4-5.9). A nearly threefold higher r isk of HPV cervical infection emerged among IVDU women (MLR-OR: 2.7, 9 5 % CI: 1.4-5.0), and this difference was not influenced by HIV serost atus. The prevalence of HIV infection was higher among HPV-positive th an HPV-negative women (62.8 % and 54.0 %, respectively) (MLR-OR = 1.9, 95 % CI: 0.9-3.8), and the proportion of women with less than 200 CD4 + cells/mm(3) was slightly and not significantly higher among HPV-posi tive (47.1 %) than negative women (37.2 %).