PLASMA-LEVELS OF PENTOSIDINE IN DIABETIC-PATIENTS - AN ADVANCED GLYCATION END-PRODUCT

Citation
S. Sugiyama et al., PLASMA-LEVELS OF PENTOSIDINE IN DIABETIC-PATIENTS - AN ADVANCED GLYCATION END-PRODUCT, Journal of the American Society of Nephrology, 9(9), 1998, pp. 1681-1688
Citations number
48
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Urology & Nephrology
ISSN journal
1046-6673
Volume
9
Issue
9
Year of publication
1998
Pages
1681 - 1688
Database
ISI
SICI code
1046-6673(1998)9:9<1681:POPID->2.0.ZU;2-P
Abstract
Nonenzymatic reactions between glucose and proteins yield advanced gly cation end products (AGE) such as pentosidine. AGE accumulate in diabe tic patients, alter the structure and function of tissue proteins, sti mulate cellular response, and have thus been implicated in diabetic ti ssue damage. The present study was undertaken to assess the factors de termining plasma total pentosidine level in diabetic patients and the possible relation between plasma pentosidine level and diabetic compli cations. In diabetic patients, including patients with renal failure, plasma pentosidine levels, assessed by HPLC assay, were correlated wit h serum creatinine (P < 0.0001). In patients with normal renal functio n, pentosidine levels were correlated with blood glucose control (hemo globin Ale: P = 0.0028; fructoselysine: P = 0.0133), serum creatinine (P = 0.029), patient age (P = 0.0416), duration of diabetes (P = 0.043 1), and total cholesterol (P = 0.0056) and LDL-chslesterol (P = 0.0208 ). Multiple regression analysis revealed an independent influence of h emoglobin Ale and serum creatinine on pentosidine levels (r(2) = 0.216 , P = 0.0026). Pentosidine levels were higher in patients with than in those without hypertension (P = 0.043) or ischemic heart diseases (P = 0.0061). No such differences were observed between patients with and without albuminuria or retinopathy. Multiple regression analysis reve aled an independent influence of plasma pentosidine on the presence of hypertension (r(2) = 0.129, P = 0.0382) and of plasma pentosidine and HDL-cholesterol on the presence of ischemic heart disease (r(2) = 0.3 26, P = 0.0012). The present study demonstrated that plasma pentosidin e level was significantly influenced by the quality of glycemic contro l and renal function. Pentosidine level was also correlated with hyper tension and ischemic heart disease, and might be taken as a biomarker of diabetic cardiovascular risk.