RECOMBINANT IFN-GAMMA TREATMENT OF A PATIENT WITH HYPERIMMUNOGLOBULIN-E SYNDROME TRIGGERED AUTOIMMUNE THROMBOCYTOPENIA

Citation
Y. Aihara et al., RECOMBINANT IFN-GAMMA TREATMENT OF A PATIENT WITH HYPERIMMUNOGLOBULIN-E SYNDROME TRIGGERED AUTOIMMUNE THROMBOCYTOPENIA, Journal of interferon & cytokine research, 18(8), 1998, pp. 561-563
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology,Immunology,"Cell Biology
ISSN journal
1079-9907
Volume
18
Issue
8
Year of publication
1998
Pages
561 - 563
Database
ISI
SICI code
1079-9907(1998)18:8<561:RITOAP>2.0.ZU;2-N
Abstract
We report a pediatric patient with hyperimmunoglobulin E syndrome (HIE S) treated with recombinant IFN-gamma (rIFN-gamma) for 2 1/4 years who developed autoimmune thrombocytopenia and was positive for serum anti platelet antibody and antinuclear antibody (ANA). She was then treated with i.v. methylprednisolone pulse therapy followed by oral immunosup pressive drugs. With this therapy, her platelet count increased and wa s maintained within the normal range for more than a year. We retrospe ctively examined her sera stored at -40 degrees C for ANA and found th at the ANA level was increased from 1:40 to 1:640 with the rIFN-gamma therapy. Therefore, we believe that, in this case, rIFN-gamma treatmen t may have played a crucial role in triggering autoimmune thrombocytop enia. Furthermore, this case demonstrates that caution must be observe d in administering rIFN-gamma to genetically predisposed patients.