PROSPECTIVE-STUDY OF C-REACTIVE PROTEIN AND THE RISK OF FUTURE CARDIOVASCULAR EVENTS AMONG APPARENTLY HEALTHY WOMEN

Citation
Pm. Ridker et al., PROSPECTIVE-STUDY OF C-REACTIVE PROTEIN AND THE RISK OF FUTURE CARDIOVASCULAR EVENTS AMONG APPARENTLY HEALTHY WOMEN, Circulation, 98(8), 1998, pp. 731-733
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Peripheal Vascular Diseas",Hematology,"Cardiac & Cardiovascular System
Journal title
ISSN journal
0009-7322
Volume
98
Issue
8
Year of publication
1998
Pages
731 - 733
Database
ISI
SICI code
0009-7322(1998)98:8<731:POCPAT>2.0.ZU;2-B
Abstract
Background-C-reactive protein (CRP) predicts risk of myocardial infarc tion (MI) and stroke among apparently healthy men, but in women, virtu ally no data are available. Methods and Results-CRP was measured in ba seline blood samples from 122 apparently healthy participants in the W omen's Health Study who subsequently suffered a first cardiovascular e vent and from 244 age- and smoking-matched control subjects who remain ed free of cardiovascular disease during a 3-year follow-up period. Wo men who developed cardiovascular events had higher baseline CRP levels than control subjects (P=0.0001), such that those with the highest le vels at baseline had a 5-fold increase in risk of any vascular event ( RR=4.8; 95% CI, 2.3 to 10.1; P=0.0001) and a 7-fold increase in risk o f MI or stroke (RR=7.3; 95% CI, 2.7 to 19.9; P=0.0001), Risk estimates were independent of other risk factors, and prediction models that in cluded CRP provided a better method to predict risk than models that e xcluded CRP tall P values <0.01). In stratified analyses, CRP was a pr edictor among subgroups of women with low as well as high risk as defi ned by other cardiovascular risk factors. Conclusions-In these prospec tive data among women, CRP is a strong independent risk factor for car diovascular disease that adds to the predictive value of risk models b ased on usual factors alone.