A PILOT-STUDY OF DEHYDROEPIANDROSTERONE-SULFATE IN MYOTONIC-DYSTROPHY

Citation
M. Sugino et al., A PILOT-STUDY OF DEHYDROEPIANDROSTERONE-SULFATE IN MYOTONIC-DYSTROPHY, Neurology, 51(2), 1998, pp. 586-589
Citations number
10
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Neurology
Journal title
ISSN journal
0028-3878
Volume
51
Issue
2
Year of publication
1998
Pages
586 - 589
Database
ISI
SICI code
0028-3878(1998)51:2<586:APODIM>2.0.ZU;2-H
Abstract
We studied the effect of TV administration of a dehydroepiandrosterone sulfate (DHEAS) preparation (200 mg/day for 8 weeks) in 11 patients w ith myotonic dystrophy (MyD). After DHEAS, activities of daily Living improved, muscle strength increased, and myotonia decreased. Conductio n block and premature beats also improved in the four patients with ca rdiac involvement. This pilot study may provide a rationale for a cont rolled study of DHEAS in MyD.