ACUTE MYELOMONOBLASTIC LEUKEMIA CARRYING THE PEBP2-BETA MYH11 FUSION GENE/

Citation
N. Asou et al., ACUTE MYELOMONOBLASTIC LEUKEMIA CARRYING THE PEBP2-BETA MYH11 FUSION GENE/, Leukemia & lymphoma, 31(1-2), 1998, pp. 81-91
Citations number
65
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Hematology,Oncology
Journal title
ISSN journal
1042-8194
Volume
31
Issue
1-2
Year of publication
1998
Pages
81 - 91
Database
ISI
SICI code
1042-8194(1998)31:1-2<81:AMLCTP>2.0.ZU;2-O
Abstract
As recurrent chromosome abnormalities in leukemia are highly associate d with particular subtypes, the genetic events of specific chromosome alteration must be associated with leukemogenesis and characteristics of the disease. The chromosomal breakpoints involved in inv(16) and t( 16;16) have been shown to generate the fusion gene PEBP2 beta(CBF beta )/MYH11. The PEBP2 beta/MYH11 fusion transcripts in all 8 patients wit h M4Eo, 2 of 18 with M4, and one CML in the blastic phase were detecte d by using RT-PCR and Southern blotting. We demonstrated the marked ex pression of CD34 and c-KIT (CD117) antigens in myelomonoblastic leukem ia cells from all patients carrying this fusion gene, which was in con trast to the patients with M4 but without the fusion gene. These resul ts indicate that immunophenotypic analysis is useful for detection of leukemia with the fusion gene, and that the PEBP2 beta/MYH11 fusion ge ne is involved in immature cells expressing CD34 and c-KI'T antigens.