ITALIAN STUDY ON COLORECTAL-CANCER WITH EMPHASIS ON INFLUENCE OF CEREALS

Citation
S. Franceschi et al., ITALIAN STUDY ON COLORECTAL-CANCER WITH EMPHASIS ON INFLUENCE OF CEREALS, European journal of cancer prevention, 7, 1998, pp. 19-23
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
ISSN journal
0959-8278
Volume
7
Year of publication
1998
Supplement
2
Pages
19 - 23
Database
ISI
SICI code
0959-8278(1998)7:<19:ISOCWE>2.0.ZU;2-I
Abstract
To elucidate the influence of diet on colorectal carcinogenesis, 1225 subjects with cancer of the colon, 728 with cancer of the rectum and 4 154 controls, hospitalized with acute non-neoplastic diseases, were in terviewed between 1992 and 1996 in six Italian areas,The validated foo d frequency questionnaire included 79 questions on food items and reci pes which were grouped into 16 food groups,After allowing for nondieta ry confounding factors and total energy intake, a significant trend to wards an increasing risk of colorectal cancer with increasing intake w as found for bread and cereal dishes (odds ratio for increase of one d aily serving 1,11), cakes and desserts (odds ratio 1.02) and refined s ugar (odds ratio 1,11), The intake of fish (odds ratio 0.53), raw and cooked vegetables (odds ratios 0.79 and 0.65, respectively) and fruit (odds ratio 0.93) showed an inverse association with risk. Wholemeal b read was consumed by only 12.5% of cases and 13.9% of controls and, at variance with refined bread, did not show a significant direct associ ation with colorectal cancer risk (odds ratio 0.88). In view of these findings, current hypotheses on the carcinogenic effects of refined st archy foods and refined sugar should be revised to take into account t he digestive physiology of carbohydrates and the possible relationship between insulin and colon cancer. The beneficial influence of most ve getables is confirmed, and a possible difference between refined and w holemeal bread is suggested. Eur J Cancer Prev 7 (suppl 2): S19-S23 (C ) 1998 Lippincott-Raven Publishers.