ALCOHOL-CONSUMPTION AND RISK OF BREAST-CANCER - A MULTICENTER ITALIANCASE-CONTROL STUDY

Citation
M. Ferraroni et al., ALCOHOL-CONSUMPTION AND RISK OF BREAST-CANCER - A MULTICENTER ITALIANCASE-CONTROL STUDY, European journal of cancer, 34(9), 1998, pp. 1403-1409
Citations number
42
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
ISSN journal
0959-8049
Volume
34
Issue
9
Year of publication
1998
Pages
1403 - 1409
Database
ISI
SICI code
0959-8049(1998)34:9<1403:AAROB->2.0.ZU;2-4
Abstract
The relationship between alcohol consumption and breast cancer risk wa s investigated using data from a co-operative case-control study condu cted in Italy between 1991 and 1994 on 2569 incident, histologically c onfirmed breast cancer cases and 2588 controls in hospital for acute, non-neoplastic, non-hormone related conditions. Overall, 915 (38%) cas es and 1048 (43%) controls were abstainers. Compared with them, the od ds ratio (OR), adjusted only for age, was 1.31 (95% confidence interva l (CI) 1.13-1.53) for drinkers and became 1.39 (95% CI 1.(1)21-1.60) a fter correction for measurement error. The multivariate OR was 1.21 fo r drinkers of less than or equal to 5.87 g/day and 1.23, 1.19, 1.21, 1 .41 for drinkers of 5.88-13.40, 13.41-24.55, 24.56-27.60, >27.60g/day, respectively. The trend in risk was significant (chi(2) = 12.28, P< 0 .0005). The association was apparently stronger in premenopausal women (OR = 1.80 for >27.60g/day). Considering the different types of alcoh olic beverages (wine, beer, digestives, grappa and other spirits), a s ignificant direct trend in breast cancer risk was seen for wine with a n OR of 1.27 (95% CI 1.06-1.53) for the category >26.34g/day. The ORs were also above unity for beer, grappa, digestives and spirits drinker s. No appreciable interaction was observed between alcohol drinking an d body mass index, smoking, or any other covariate considered. Thus, t he present data, based on a validated alcohol consumption questionnair e and on a population characterised by a relatively high alcohol consu mption in women, confirmed that alcohol drinking is moderately related to breast cancer risk. If causal, this association could explain 12% (95% CI, 5-19%) of breast cancers in Italy, thus representing one of t he major avoidable risk factor for breast cancer. (C) 1998 Elsevier Sc ience Ltd. All rights reserved.