FIBER INTAKE AND RISK OF COLORECTAL-CANCER

Citation
E. Negri et al., FIBER INTAKE AND RISK OF COLORECTAL-CANCER, Cancer epidemiology, biomarkers & prevention, 7(8), 1998, pp. 667-671
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Public, Environmental & Occupation Heath
ISSN journal
1055-9965
Volume
7
Issue
8
Year of publication
1998
Pages
667 - 671
Database
ISI
SICI code
1055-9965(1998)7:8<667:FIAROC>2.0.ZU;2-7
Abstract
The relationship between various types of fiber and colorectal cancer risk was investigated using data from a case-control study conducted b etween January 1992 and June 1996 in Italy. The study included 1953 ca ses of incident, histologically confirmed colorectal cancers (1225 col on cancers and 728 rectal cancers) admitted to the major teaching and general hospitals in the study areas and 4154 controls with no history of cancer admitted to hospitals in the same catchment areas for acute nonneoplastic diseases, Dietary habits were investigated using a vali dated food frequency questionnaire. Odds ratios (ORs) were computed af ter allowance for age, sex, and other potential confounding factors, i ncluding physical activity and protein, fat, and carbohydrate intake. Fiber was analyzed both as a continuous variable and in quintiles, For most types of fiber, the OR of colon and rectal cancers was significa ntly below 1, and no appreciable differences emerged between the two. When the unit was set at the difference between the upper cutpoints of the fourth and first quintile, i,e,, the 80th and 20th percentiles, t he ORs for colorectal cancer were 0.68 for total fiber (determined by the Englyst method as nonstarch polysaccharides), 0.67 for soluble non cellulose polysaccharides (NCPs), 0.71 for total insoluble fiber, 0.67 for cellulose, 0.82 for insoluble NCPs, and 0.88 for lignin, When fib er was classified according to the source, the OR was 0.75 for vegetab le fiber, 0.85 for fruit fiber, and 1.09 for cereal fiber, The ORs wer e similar for the two sexes and the strata of age, education, physical activity, family history of colorectal cancer, and energy intake. Lik ewise, no appreciable differences emerged when subsites of the colon a nd rectum were investigated separately. This study provides additional support for a protective and independent effect of fiber on colorecta l cancer, particularly for cellulose and soluble NCPs, and of fiber of vegetable or fruit origin.