METAANALYSIS OF ALCOHOL INTAKE IN RELATION TO RISK OF LIVER-CIRRHOSIS

Citation
G. Corrao et al., METAANALYSIS OF ALCOHOL INTAKE IN RELATION TO RISK OF LIVER-CIRRHOSIS, Alcohol and alcoholism, 33(4), 1998, pp. 381-392
Citations number
51
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Substance Abuse
Journal title
ISSN journal
0735-0414
Volume
33
Issue
4
Year of publication
1998
Pages
381 - 392
Database
ISI
SICI code
0735-0414(1998)33:4<381:MOAIIR>2.0.ZU;2-N
Abstract
The heterogeneity in the results of observational studies that investi gated the association between alcohol consumption and risk of liver ci rrhosis was analysed by means of a meta-analysis that included 15 arti cles published from 1978 to 1997. Relative risks associated with low l evels of alcohol intake (25 g/day) ranged from 1.5 [95% confidence int erval (CI): 1..4-1.5] for a linear model fitting the results of the si x studies performed in Mediterranean areas, to 3.6 (95% CI 3.1-4.3) fo r a quadratic model fitting the results of the nine studies performed in other areas. A strong indication of heterogeneity was observed when combining all studies. Quadratic term of alcohol intake, quality of t he study and area in which the study was performed explained most of t his heterogeneity. Efforts should be made to explain the strong hetero geneity in the trend estimates. Reproducible methods to collect releva nt and valid information on alcohol intake should be developed and the role of drinking patterns and viral and nutritional factors in modify ing the effect of alcohol on the risk of liver cirrhosis should be inv estigated.