WATER-SOLUBLE HOLLOW NANOSPHERES AS POTENTIAL-DRUG CARRIERS

Authors
Citation
Jf. Ding et Gj. Liu, WATER-SOLUBLE HOLLOW NANOSPHERES AS POTENTIAL-DRUG CARRIERS, JOURNAL OF PHYSICAL CHEMISTRY B, 102(31), 1998, pp. 6107-6113
Citations number
29
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry Physical
Journal title
JOURNAL OF PHYSICAL CHEMISTRY B
ISSN journal
1520-6106 → ACNP
Volume
102
Issue
31
Year of publication
1998
Pages
6107 - 6113
Database
ISI
SICI code
1089-5647(1998)102:31<6107:WHNAPC>2.0.ZU;2-Z
Abstract
A polyisoprene-block-poly(2-cinnamoylethyl methacrylate) (PI-b-PCEMA) sample with 88 units of isoprene and 2.3 x 10(2) units of CEMA formed vesicles in THF/hexanes with hexanes volume fractions between 50% and 95%. The vesicles had PCEMA as the shell and PI chains stretching into the solution phase from both the inner and outer surfaces of the PCEM A shell. The cavity diameter of the vesicles is similar to 38 nm, and the volume fraction of PI chains there is low. After the PCEMA shell w as cross-linked, the PI chains were converted to water-soluble poly(2, 3-dihydroxyl-2-methyl-butane) chains. The water-soluble hollow nanosph eres uptook a large amount of rhodamine B in methanol and released the compound into water at a tunable rate depending on the amount of etha nol added to the aqueous medium. This study demostrates the potential of hollow nanospheres, prepared from tailor-made biocompataible and de gradable polymers, as drug carriers in controlled drug release applica tions.