CHEMOTAXIS AND CHEMOTACTIC SELECTION INDUCED WITH CYTOKINES (IL-8, RANTES AND TNF-ALPHA) IN THE UNICELLULAR TETRAHYMENA-PYRIFORMIS

Authors
Citation
L. Kohidai et G. Csaba, CHEMOTAXIS AND CHEMOTACTIC SELECTION INDUCED WITH CYTOKINES (IL-8, RANTES AND TNF-ALPHA) IN THE UNICELLULAR TETRAHYMENA-PYRIFORMIS, Cytokine (Philadelphia, Pa. Print), 10(7), 1998, pp. 481-486
Citations number
54
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell Biology",Biology,Immunology
ISSN journal
1043-4666
Volume
10
Issue
7
Year of publication
1998
Pages
481 - 486
Database
ISI
SICI code
1043-4666(1998)10:7<481:CACSIW>2.0.ZU;2-R
Abstract
Three representative cytokines interleukin (IL-8), RANTES and tumour n ecrosis factor alpha (TNF-alpha) have a concentration-dependent chemot actic effect on the unicellular Tetrahymena. Maximal effective concent rations of IL-8 (1 ng/ml) and RANTES (75 ng/ml) are in the same range as in mammals, which indicates an evolutionary background of physiolog ical effects elicited. Progeny generations of cells selected for their affinity to cytokines (IL-8 and TNF-alpha) show an enhanced positive chemosensory reaction to the cytokines, The changed reaction of these cells to the chemoattraction of the culturing medium was also observed . The results call attention to the presence of cytokine-dependent pro cesses at a low phylogenetic level. (C) 1998 Academic Press.