INHIBITORY EFFECTS OF ANTIRHEUMATIC DRUGS CONTAINING MAGNOSALIN, A COMPOUND FROM SHIN-I (FLOS-MAGNOLIAE), ON THE PROLIFERATION OF SYNOVIAL-CELLS IN RHEUMATOID-ARTHRITIS MODELS

Citation
S. Kobayashi et al., INHIBITORY EFFECTS OF ANTIRHEUMATIC DRUGS CONTAINING MAGNOSALIN, A COMPOUND FROM SHIN-I (FLOS-MAGNOLIAE), ON THE PROLIFERATION OF SYNOVIAL-CELLS IN RHEUMATOID-ARTHRITIS MODELS, Immunopharmacology, 39(2), 1998, pp. 139-147
Citations number
40
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
ISSN journal
0162-3109
Volume
39
Issue
2
Year of publication
1998
Pages
139 - 147
Database
ISI
SICI code
0162-3109(1998)39:2<139:IEOADC>2.0.ZU;2-R
Abstract
This study was undertaken to examine the effects of magnosalin, a comp ound isolated from 'Shin-i' (Flos magnoliae) on proliferation of synov ial cells isolated from MRL/1pr and collagen-induced arthritis (CIA) m ice, and rheumatoid arthritis (RA) patients. Magnosalin (2.39-23.9 mu M) inhibited 5% fetal bovine serum (FBS)-stimulated [H-3]-thymidine in corporation into the synovial cells in the MRL/1pr mice. The effect of magnosalin was greater than that of hydrocortisone, bucillamine and m agnoshinin (another compound from 'Shin-i'), but weaker than that of c orticosterone. The effects of magnosalin for FBS-induced thymidine inc orporation into the cells of the CIA mice and the RA patients were sig nificantly greater than those in the corresponding control mice and os teoarthritis patients, Interleukin (IL)-1 alpha increased the incorpor ation of thymidine into the synovial cells in the C57BL/6J mice to a g reater degree than did basic fibroblast growth factor (bFGF) or platel et-derived growth factor BB-homodimer (PDGF-BB). The inhibitory effect of magnosalin on the submaximal action of IL-1 alpha was significantl y greater than that of bFGF, PDGF-BB or FBS, These results offer evide nce that magnosalin suppresses the proliferation of synovial cells in RA models by inhibiting IL-1 alpha-stimulated action. (C) 1998 Elsevie r Science B.V. All rights reserved.